In the Undoctored program and the Undoctored Inner Circle, we all begin with the same program that I call Wild, Naked, and Unwashed. I gave it this crazy name because it means that we, in effect, revert back to life the way it was supposed to be conducted all along before absurd dietary guidelines, processed garbage foods, Big Pharma, doctors and healthcare got in the way. Hundreds of health conditions reverse just by following the basic Undoctored program.
But not all health conditions fully respond to the basic program. For this reason, we have what we call Undoctored Protocols and Undoctored Advanced Topics to address conditions that do not fully respond to basic efforts. Migraine headaches is among those conditions. Preventing Migraine Headaches is therefore among the Undoctored Advanced Topics that we cover. And among the more advanced issues we consider is MTHFR gene variants, an issue I highly doubt your primary care doctor or neurologist considered:
Higher homocysteine blood levels are associated with migraine headaches, while reduction of homocysteine with B vitamins (folates, B12, B6, and B2) correlates with reduction in severity and intensity of migaines. (Note that higher blood homocysteine levels also predict greater likelihood of depression and cognitive impairment/dementia.) In addition, the fairly common MTHFR gene variant, C677T, carried by 12-25% of people, causes poor absorption of folate (vitamin B9), reflected by increased blood levels of homocysteine. People with migraines have a greater likelihood of carrying the C677T gene variant and are therefore more susceptible to the effects of low folate and higher homocysteine levels.
In one study, for example, a combination of folic acid 2 mg + vitamin B6 25 mg + vitamin B12 400 mcg vs. placebo was shown to reduce migraine frequency by 75%, severity by 25%, along with 39% reduction in homocysteine from a starting level of 10.8 micromol/L (a level regarded as “normal” in most lab reports). Benefits were most marked in carriers of the MTHFR C677T genotype. Riboflavin has also been shown to reduce migraines; see below in the discussion re: mitochondrial dysfunction.
Unfortunately, the methyl-form of folate that is more effective in increasing blood folate levels in people with MTHFR C677T has not been explored in any clinical study, but should be expected to be more effective in both reducing homocysteine and frequency/severity of migraine headaches than synthetic folic acid or folates and side-steps the suspected increased cancer rate that may occur with folic acid (due to higher blood levels of unmetabolized folic acid). Interestingly, SIBO is not uncommonly associated with poor absorption of folate and B12, potentially magnifying deficiency of these nutrients, especially in those with the MTHFR C677T variant.